This is Volume 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery. To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. For a complete list of articles and contributors as well as FREE sample chapters from this new 6th Edition please visit: www mrw.interscience.wiley.com/bmcdd
Table of Contents
History of Quantitative Structure-Activity Relationships (C. Selassie).Recent Trends in Quantitative Structure-Activity Relationships (A. Tropsha).Molecular Modeling in Drug Design (G. Marshall & D. Beusen).Drug-Target Binding Forces: Advances in Force Field Approaches (P. Kollman & D. Case).Combinatorial Library Design, Molecular Similarity, and Diversity Applications (J. Mason & S. Pickett).Virtual Screening (I. Muegge & I. Enyedy).Docking and Scoring Functions/Virtual Screening (C. Sotriffer, et al.).Bioinformatics: Its Role in Drug Discovery (D. Parry-Smith).Chemical Information Computing Systems in Drug Discovery (D. Henry).Structure-Based Drug Design (L. Hardy & M. Safo).X-Ray Crystallography in Drug Discovery (D. Livington, et al.).NMR and Drug Discovery (D. Craik & R. Clark).Mass Spectrometry and Drug Discovery (R. van Breemen).Electron Cryomicroscopy of Biological Macromolecules (R. Henderson).Peptidomimetics for Drug Design (M. Estiarte & D. Rich).Analog Design (J. Cannon).Approaches to the Rational Design of Enzyme Inhibitors (M. McLeish & G. Kenyon).Chirality and Biological Activity (A. Draffan, et al.).Structural Concepts in the Prediction of the Toxicity of Therapeutical Agents (H. Rosenkranz).Natural Products as Leads for New Pharmaceuticals (A. Buss, et al.).Index.
DONALD A. ABRAHAM, PhD, is Professor and Chairman of the Department of Medicinal Chemistry at the Virginia Commonwealth University School of Pharmacy. A world-renowned leader in medicinal chemistry and biotechnology, he is the author of more than 140 journal citations and twenty-five patents. He was selected by the AACP Board of Directors as the recipient of the 2002 AACP Paul Dawson Biotechnology Award.