Obesity is a heterogeneous condition and risk of related health outcomes in different obesity phenotypes is a controversial subject. In this study, we aimed to evaluate the risk of cardiovascular disease (CVD) and all-cause mortality in different abdominal obesity phenotypes during a decade-long follow-up. In this large population-based cohort, 7122 participants (42.7% men), aged 30 years, from the Tehran Lipid and Glucose Study (TLGS) were enrolled. MHAO was defined as abdominal obesity (waist circumference >=91cm for women and >=89 cm for men) with healthy metabolic profile with less than 2 criteria from joint interim statement (waist not included). Then, all-cause mortality risk and CVD, adjusted for age and sex were estimated using Cox proportional hazards models.