Having been dismissed by Maternity Hospital, Dr. William Masters (Michael Sheen) needs a place where he and Virginia Johnson (Lizzy Caplan) can resume their work. But thanks to their study’s contro­versial topic – sex – they are forced out of two more hospitals before deciding to open their own clinic.
With the seeds of the sexual revolution being sown and the simmering civil rights movement exploding around them, the intimate relationship they started under the guise of their research unravels as the result of Masters’ sudden impotence.
With the prospect of treating sexual dysfunction becoming increasingly important to their patients and themselves, at home Masters confronts his wife’s growing disaffection and the unexpected return of his estranged brother, while Johnson faces a crisis of her own when the publicity surrounding their work places the custody of her two children in doubt.