The Human Centipede 3 (Final Sequence) is an upcoming Dutch horror film written and directed by Tom Six and the third and final installment in Six's Human Centipede trilogy.

Bully prison warden Bill Boss, leading a big state prison in the US of A, has a lot of problems; his prison statistically has the highest amount of prison riots, medical costs and staff turnover in the country. But foremost he is unable to get the respect he thinks he deserves from his inmates and the state Governor. He constantly fails in experimenting with different ideas for the ideal punishment to get the inmates in line, which drives him, together with the sizzling heat, completely insane. Under threats of termination by the Governor, his loyal right hand man Dwight comes up with a brilliant idea. A revolutionary idea which could change the American prison system for good and save billions of dollars. An idea based on the notorious ‘Human Centipede’ movies, that will literally and figuratively get the inmates on their knees, creating the ultimate punishment and deterrent for anyone considering a life of crime. Having nothing to lose, Bill and Dwight create a jaw-dropping 500-person prison centipede.