Pathophysiology and Treatment of Atherosclerotic Disease in Peripheral Arteries is a thorough review of the disease written by experts studying its detection and treatment. These state-of-the-art chapters summarize emerging knowledge about this important area of medicine. The pathophysiology and treatment of peripheral artery (PAD) disease remains poorly understood even by practitioners. Often it is assumed that PAD should be treated in a similar fashion to coronary artery disease (CAD), when in fact recent data suggest a distinct pathophysiology with genetic risk having some but not complete overlap with CAD. This is a novel reference of emerging data on the factors behind its development and progression, detection, and treatment suggest an emerging paradigm for this disease.