Molecular Machines in Biology

The concept of molecular machines in biology has transformed the medical field in a profound way. Many essential processes that occur in the cell, including transcription, translation, protein folding and protein degradation, are all carried out by molecular machines. This volume focuses on important molecular machines whose architecture is known and whose functional principles have been established by tools of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited volume includes contributions from prominent scientists and researchers who understand and have explored the structure and functions of these machines. This book is essential for students and professionals in the medical field who want to learn more about molecular machines.

Author Biography

Dr Joachim Frank is a Howard Hughes Medical Institute Investigator, Professor of Biochemistry and Molecular Biophysics and Professor of Biological Sciences at Columbia University. He has received many awards for his research, including, with David DeRosier, the Elizabeth Robert Cole Award of the Biophysics Society. He has published more than 200 peer-reviewed articles, written numerous book chapters and authored or edited five books, including Electron Crystallography of Biological Macromolecules, edited with Kenneth Downing, David DeRosier and Wah Chiu (2007) and Electron Tomography, 2nd edition (2010).