Enzymes in Neurodegenerative Disorders

This book delves into the correlation between different enzymes and neurodegenerative disorders. It investigates the intricate processes that contribute to the decline of cognitive functions, memory impairment, and other incapacitating symptoms of Alzheimer’s disease. The book examines the roles of diverse enzymes in Amyotrophic Lateral Sclerosis and their effects on the motor neurons, leading to muscle weakness, paralysis, and eventual fatality. Moreover, it examines the association between depression and the enzymes responsible, providing a fresh viewpoint on the biochemical foundation of this ailment. Lastly, the book explores the connection between enzymes and Parkinson’s disease, discussing the mechanisms that cause the death of dopamine-producing neurons and the related symptoms. By examining the functions of various enzymes in Parkinson’s disease, the book presents a distinct outlook on the intricate interplay between enzymes and several neurological conditions, imparting readers with a comprehensive understanding of the fundamental mechanisms that underlie these disorders.

Author Biography

Dr. Bijo Mathew is a Professor of the Pharmaceutical Chemistry department at the Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, India. Dr. Bijo Mathew obtained his M.Pharm in Pharmaceutical Chemistry from The Tamilnadu Dr. M.G.R. Medical University, Tamilnadu, India, in 2008 and Ph.D. in Pharmaceutical Sciences from Jawaharlal Nehru Technological University, Hyderabad, India in 2016. Mathew’s primary focus areas are drug discovery of neurodegenerative disorders, cancer, and molecular modeling. His main research interest is in the design of enzyme inhibitors, especially MAOs, ChEs, and BACE1. He received the Top 2% Scientists category from the world Stanford’s list in 2021 to 2023. He has published 230 papers, [h-index = 43; the number of citations: 6011 in Google Scholar), (h-index = 40; the number of citations: 5070 in Scopus) [July 2024]. With 16 years of teaching and research experience, Mathew authored one book, one edited book, seven book chapters, and 34 invited talks at national and international levels. Dr. B. Mathew serves as a chief executive guest editor of the journals Molecules, Current Topics in Medicinal Chemistry, and Current Drug Targets. He serves on the editorial board of journals Brain Sciences and Combinatorial Chemistry and High Throughput Screening. For the development of MAO inhibitor drugs, Dr. Mathew obtained funds from many government funding organisations in India, including DRDO and ICSSR. He received Amrita Vishwa Vidyapeetham Chancellor’s Publication and Merit awards in 2021 and 2024. He received three patents from the Korean and German Intellectual Property of office.

Dr. Della Grace Thomas Parambi is presently working as Asst. Professor in the Department of Pharmacy, Jouf University. She has accomplished her Ph.D. in Pharmaceutical analysis. She has earlier served as Head and Principal of Triveni Institute of Pharmacy, Thrissur. She has more than 20 years of teaching experience in Analytical Chemistry, Medicinal Chemistry, Molecular Modeling, and Drug Design. The primary research activities are focused on the design of MAO/ChE inhibitors for neurodegenerative disorders. Several of her publications have fetched the “most downloaded paper award for the year 2018-2020. She has also published more than 70 research articles in peer-reviewed international journals and authored one book and 6 book chapters. She is a member of many international scientific societies and organizations importantly, including the Indian Society of science and Technology, and also an EVC expert in the All-India Council for Technical Education (AICTE). She has received many awards including AIAF-IEDRA-Indian Leadership Award for Education Excellence Award for the year 2014 and also the IAF-Best Performing Institution of the Year Award 2014.