Located near the U. S. Amundsen-Scott Research Station at the geographic South Pole, IceCube is unlike most telescopes in that it is not designed to detect light. It employs a cubic kilometre of diamond-clear ice, more than a mile beneath the surface, to detect an elementary particle known as the neutrino. In 2010, it detected the first extraterrestrial high-energy neutrinos and thus gave birth to a new field of astronomy. IceCube is also the largest particle physics detector ever built. Its scientific goals span not only astrophysics and cosmology but also pure particle physics. And since the neutrino is one of the strangest and least understood of the known elementary particles, this is fertile ground. Neutrino physics is perhaps the most active field in particle physics today, and IceCube is at the forefront. The Telescope in the Ice is, ultimately, a book about people and the thrill of the chase: the struggle to understand the neutrino and the pioneers and inventors of neutrino astronomy.