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The HERG Cardiac Potassium Channel

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The HERG Cardiac Potassium Channel

Structure, Function and Long QT Syndrome

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The HERG Cardiac Potassium Channel by Novartis Foundation
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Description

This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug--induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channel in drug--induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.
Release date NZ
February 11th, 2005
Country of Publication
United Kingdom
Illustrations
Illustrations
Imprint
John Wiley & Sons Ltd
Pages
308
Dimensions
165x237x19
ISBN-13
9780470021408
Product ID
3089590

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