Excerpt from The American Journal of Anatomy, Vol. 28: November, 1920-March, 1921 Those who have tried to solve this problem experimentally have ligatured the pancreatic duct, allowed the animal to fast, or in jected pilocarpin or secretin, and studied the changes thus pro duced in the size and number of the islets. Their Observations have not, however, been in accord. Some (fischer, Dale, and Vincent and Thompson) believed that they found an increase in the number of islets in starvation, while others noticed neither an increase nor a decrease of the islet tissue. On the other hand, ligature of the pancreatic duct caused, in some instances, the dis appearance Of only the acinus tissue, the islet remaining intact; in others, the disintegration of both tissues. That lack of uni formity in the results of these experimental investigations is perhaps due primarily to an inequality in the experimental methods employed; secondly, to the fact that the islets vary greatly in size and number not only in the different animals, but also in different portions of the same pancreas, as has been pointed out by various investigators. Under these circumstances there is always a danger of misinterpretation when one attempts to draw any general conclusion from the changes in Size and num ber of islets in any circumscribed area Of the pancreas. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.