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Stabilized Helical Peptide Therapeutics



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Stabilized Helical Peptide Therapeutics by Zigang Li

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  • 7-9 May using standard courier delivery
    Unlikely to arrive before Christmas


This book covers current methodologies of constructing constrained helices, including their features and limitations. The effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration and nonspecific toxicity are also substantially summarized and discussed. Furthermore, therapeutic applications of the constraint helices, including comparison with existing small molecule modulators or antibodies are also included. This book will give readers outside the field a comprehensive introduction and readers inside the field a deeper understanding, thus it will help researchers to further advance the field or choose proper achievement of the field to solve practical problems.

Author Biography

Zigang Li is now a professor in School of Chemical Biology and Biotechnology of Peking University. Before joining Peking University, Li worked as a postdoctoral fellow with Professor Gregory L. Verdine at Harvard University where he focused on discovery of new targets from human cancer cells for stapled peptides. Li received his PhD with Professor Chuan He at the University of Chicago in 2008 where he investigated global regulator functions on the pathogenesis of Staphylococcus aureus. Before that, Li performed his master studies at Tulane University, where he studied with Professor Chao-Jun Li on imine reactivity in aqueous media. Li completed his undergraduate degree of biophysics at The University of Science and Technology of China. Li?s research interests include peptide based drug discovery and new strategies against infectious disease. He has published over 40 papers on journals including Chem. Rev., Nature Chem. Bio., PNAS, JACS, Angew. Chem. Int. Ed., Chem. Sci., Cell Chem. Biol., Chem. Commun., etc. Hui Zhao is now a PhD candidate in chemical biology from Peking University Shenzhen Graduate School, expected to graduate in 2017 July. During his PhD studies he worked with Professor Zigang Li on development of peptide stabilization methodologies and applications of them to cancer therapeutics interventions. Prior to PhD studies, he obtained bachelor degree in Pharmacy in Henan University in 2012.
Release date NZ
May 1st, 2019
Country of Publication
Wiley-VCH Verlag GmbH
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