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Cyclized Helical Peptides

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Cyclized Helical Peptides

Synthesis, Properties and Therapeutic Applications
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Hardback
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Description

An important and timely guide to the progress being made on constrained helical peptides Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity. The book examines the therapeutic applications of the constraint helices and includes comparison with existing small molecule modulators or antibodies. Designed as a useful resource for both those outside and inside the field. Those new to the field will find a comprehensive introduction to cyclized helical peptide and those inside the field will find a deeper understanding of the topic. This important book: Offers a practical introduction to constrained helical peptides Includes all aspects of constrained helical peptides Includes information on the most recent methods that have emerged Presents a guide to help solve practical problems in the field Written for academics, pharmaceutical professional, Cyclized Helical Peptides is a comprehensive guide to the developments of constrained helical peptides.

Author Biography:

Zigang Li is a professor in School of Chemical Biology and Biotechnology of Peking University, and the executive deputy director and senior researcher in the Shenzhen Bay Laboratory Pingshan Translational Medicine Center. Hui Zhao is an investment manager of Shenzhen Angel FOF, with experience in industry research and investment, in the field of innovative drugs and medical devices. Chuan Wan is a post-doctoral student under the supervision of Prof. Zigang Li.
Release date NZ
July 21st, 2021
Audience
  • Professional & Vocational
Pages
240
Dimensions
170x244x18
ISBN-13
9783527343423
Product ID
27875376

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