KAINE & SPIDER-WOMAN lead a rough and ready crew of Spiders on a mission to save the multi-verse that will almost certainly lead to their deaths! Spiders you love and a few new ones will risk it all to stop the Inheritors from unleashing the ultimate foe! All hands are needed in the fight to defeat the Inheritors-this time for good! Meanwhile: Anya Corazon leads a hopeful team of young heroes to investigate a legend of the Spider Society that may hold the key. If science brought the Inheritors back, maybe ancient magic can put them away.