Spectroscopic and Mechanistic Studies of Dinuclear Metallohydrolases and Their Biomimetic Complexes

By:

Lena Josefine Daumann

Format:

Hardback

Series:

Springer Theses

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Description

Lena Daumanns's thesis describes structural and functional studies of the enzyme Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. It also examines the properties of small mimics of this enzyme and related binuclear metallohydrolases such as the metallo-ß-lactamases to enhance our understanding of hydrolytic cleavage of important substrates like phosphoesters and β-lactams. Overall, this project has led to a better understanding of the metal ion binding and active site structural features of the enzyme GpdQ. Daumann describes how she successfully immobilized phosphoesterase and related biomimetics on solid supports for potential applications in the area of bioremediation of organophosphate pesticides. Analysis shows that both the enzyme and biomimetics can be stored on the solid support without loss of activity. Furthermore, the author specroscopically and mechanistically characterized a number of Zn(II), Cd(II) and Co(II) complexes, some of which are among the most active biomimetics towards organophosphates reported to date. This thesis makes excellent reading for non-specialists because each chapter includes a short introduction section.

Author Biography:

Lena Daumann holds a Diploma in Chemistry from the University of Heidelberg, Germany, where she worked with Professor Peter Comba. After gathering six months industrial experience at the BASF chemical company, she commenced her PhD in 2010 at the University of Queensland, Australia, under the supervision of Professor Lawrence Gahan. She received her doctoral degree in 2013 in the field of Bioinorganic Chemistry and currently holds a position as a postdoctoral researcher at the University of California, Berkeley, in the group of Professor Kenneth Raymond, funded by a fellowship of the Humboldt Foundation.

Release date NZ

June 13th, 2014

Author

Lena Josefine Daumann

Audience

Professional & Vocational

Illustrations

22 Illustrations, color; 178 Illustrations, black and white; XXI, 239 p. 200 illus., 22 illus. in color.

Pages

239

Series

Springer Theses

Dimensions

155x235x20

ISBN-13

9783319066288

Product ID

22282063

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