The purpose of this book is to give an overview of the whole topic in human autonomic reflexes on the basis of the trigemino-cardiac reflex (TCR) that is the strongest autonomic reflex that is known in humans. The author provides an overview of the literature, presents his own data on TCR and critically discusses the literature and his own data in a third section. In addition, he gives some insight in ongoing research projects on this topic. There will be a clinical point of view that is always in the light of result of the basic-research. This book is therefore the first publication on this important topic that deeply explains the physiological function of the TCR that was first described by the author in 1999.