Most of the familiar headache drugs are used to stop a headache attack that is already in progress, or about to begin. However, there is now a growing body of research aimed at developing medications that can be taken on a regular basis to prevent headaches from starting. These drugs will be targeted at patients whose headaches are frequent or who get their headaches at predictable times. This book reviews the potential for prophylactic treatment of headache. It provides most of the existing evidence in the field of pharmaco-prophylaxis of migraine and other chronic headaches and may thus, serve as a platform for new initiatives in the field. The book reviews the research into the pharmacological mechanisms involved, the classes of drugs in development and the clinical trials methodology. The editors have gathered together the leading international experts to produce a book that will appeal neurologists caring for headache patients, researchers in the field and those based in the pharmaceutical industry.