Reuven Zimlichman is Chief of the Department of Medicine, Head of the Hypertension Institute at the E. Wolfson Medical Center, Israel, Director of ‘The Brunner Cardiovascular Research Institute’, Tel-Aviv University and Director of the 'Institute for Quality in Medicine', Israeli Medical Association. He is also a former Vice Dean and Head of School of the Continuing Education program at the Sackler Faculty of Medicine, Tel Aviv University. Zimlichman has published more than 200 papers, 5 books and numerous book chapters. His publications are in the fields of basic research, cell cultures, animal research and clinical research and cover clinical areas including hypertension, cardiovascular disease, metabolic syndrome, end organ damage and evaluation of arterial properties. Stevo Julius, Professor Emeritus at the University of Michigan Cardiovascular Center, is one of the early pioneers in the field of hypertension whose work has focused on not only treating hypertension, but on preventing it. He has over the years addressed major questions concerning the relation of sympathetic activity and heart rate to hypertension and its complications. He has led or participated in the most innovative therapeutic trials and also distinguished himself as an educator, training two generations of teachers and researchers. He has led the International Society of Hypertension  and other clinical societies. Julius is the author of over 300 papers and book chapters and is Member of the Editorial Board on a number of journals on Hypertension. Giuseppe Mancia is a Professor Emeritus of the University of Milano-Bicocca and served as Professor of Medicine and Head of the First Division of Medicine at the San Gerardo Hospital, Italy. He is executive officer of the European Society of Hypertension and Chair of the ESH Educational Committee. Mancia’s research interests are focused on the pathophysiology, diagnosis and therapy of hypertension, heart failure, coronary and other cardiovascular diseases. His fields of expertise include ambulatory blood pressure monitoring, neural control of circulation, large artery mechanics, and clinical trials.