Dr. Arnold Katz's internationally acclaimed classic is now in its thoroughly revised Fourth Edition, incorporating the latest molecular biology research and extensively exploring the clinical applications of these findings. In a readable style enhanced by more than 400 diagrams, Dr. Katz provides a comprehensive overview of the physiological and biophysical basis of cardiac function, beginning with structure and proceeding to biochemistry, biophysics, and pathophysiology in arrhythmias, ischemia, and heart failure. This edition features a new clinical applications section and expanded chapters on the ischemic heart and heart failure.
Table of Contents
STRUCTURE, BIOCHEMISTRY, AND BIOPHYSICS Structure of the Heart and Cardiac Muscle Energetics and Energy Production Energy Utilization (Work and Heat) The Contractile Proteins The Cytoskeleton Active State, Length-Tension Relationship, and Cardiac Mechanics Excitation-Contraction Coupling: Extracellular and Intracellular Calcium Cycles SIGNAL TRANSDUCTION AND REGULATION Signal Transduction: Functional Signaling Signal Transduction: Proliferative Signaling Regulation of Cardiac Muscle Performance: Functional and Proliferative Mechanisms NORMAL PHYSIOLOGY The Heart as a Muscular Pump The Working Heart Cardiac Ion Channels The Cardiac Action Potential CLINICAL PHYSIOLOGY The Electrocardiogram Arrhythmias The Ischemic Heart Heart Failure