Perdita Durango meets Romeo Dolorosa, a criminal who is some sort of priest of a satanic cult and keeps crossing the Mexican-US border safely. He's asked to do a job for crime boss Santos, involving the traffic of human foetuses for the cosmetic industry. Meanwhile, he needs to make a sacrifice to please his gods and a young American couple comes in his and Perdita's way. They are being followed by an unlucky DEA agent, the father of the kidnapped girl, an old partner which Romeo double-crossed and the previous boss to whom he owes a lot of money. He doesn't like what he reads in the cards...

'The seductions of Perdita Durango include every trick in Tarantino's book. "From Dusk Till Dawn" times 10,000' -The Sydney Morning Herald.