There have been significant advances in the application of instrumentation to elucidate chemical structures - from the smallest molecule to the largest biopolymer. Although knowledge of these static structures has made an invaluable contribution to chemistry and biology, it is the understanding of the dynamic interconversion of these structures which remains an intriguing challenge. This text provides a comprehensive and detailed discussion of the investigation of organic and bioorganic reaction mechanisms. It addresses questions such as: 'How are bonds between atoms rearranged?', 'What sort of structural changes take place to cause bond fission and formation?' and 'How do catalysts lower the activation energies of reactions?'.*Techniques for diagnosis of mechanism not previously compiled from research literature.*An important bridge between fundamental studies and mechanisms in solution.*Key references from classic papers to the latest research literature.