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Non-Myeloablative Allogeneic Transplantation

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Description

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.
Release date NZ
October 30th, 2012
Audience
  • Professional & Vocational
Contributors
  • Edited by Asad Bashey
  • Edited by Edward D. Ball
Edition
Softcover reprint of the original 1st ed. 2002
Illustrations
X, 216 p.
Pages
216
Dimensions
156x234x12
ISBN-13
9781461353041
Product ID
21280875

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Books >
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Medicine >
Clinical & internal medicine >
Diseases & disorders >
Oncology
Books >
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Professional & Technical >
Medicine >
Surgery >
Transplant surgery