The most devious plan ever created in a Nicktoons world is unfolding. Professor Calamitous has pulled together Plankton, Vlad, and Crocker to form a group known as The Evil Syndicate. The wicked foursome have begun to wreak havoc throughout Retroville, Amity Park, Dimmsdale, and Bikini Bottom in an attempt to take over the world.
Not to be outsmarted, Jimmy Neutron calls upon his own band of Nicktoons. Jimmy, Timmy, Danny, and SpongeBob SquarePants combine their powers to take out The Evil Syndicate, along with the devastating Doomsday device. It's good versus evil where only one side will prevail.