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Metabolic Drug Interactions

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Metabolic Drug Interactions



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Metabolic Drug Interactions by Rene Levy
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This volume brings together the large body of recent research on metabolic drug interactions and their relevance in the treatment of diseases. The book focuses on human metabolic enzyme systems that have been shown in vitro to be predictive of drug interactions. Major sections present information on specific therapeutic classes of drugs as substrates, inhibitors, and inducers of metabolic enzymes. Other chapters discuss the clinical and pharmacoeconomic implications of metabolic drug interactions and the significance of in vitro metabolic studies in new drug development

Table of Contents

Section I: Prediction of Drug Interactions From In Vitro Studies: Basic Principles 1. Metabolically-Based Drug-Drug Interactions: Principles and Mechanisms 2. From In Vitro to In Vivo: An Academic Perspective 3. Industrial Viewpoint: Application of In Vitro Drug Metabolism in Various Phases of Drug Development 4. Regulatory Viewpoint: Prediction of Drug Interactions from In Vitro Studies Section II: Enzymes and Transporters 5. Cytochromes P450: Historical Overview 6. CYP1A 7. CYP2C 8. CYP2D6 9. CYP2E1 10. CYP3A 11. Glycoprotein 12. Other CYP: 2A6, 2B6, 4A 13. UDP-Glucuronosyltransferases 14. Glutathione S-Transferases 15. Sulfotransferases and Methyltransferases 16. Epoxide Hydrolases Section III: Drugs As Substrates of Metabolic Enzymes Treatment of CNS Diseases 17. Anticonvulsants 18. Antidepressants 19. Antipsychotics 20. Sedative-Hypnotic and Anxiolytic Agents 21. Volatile, Intravenous, and Local Anesthetics 22. Opioid Analgesics 23. Agents for the Treatment of Migraine, Parkinson's, and Alzheimer's Diseases Treatment of Cardiovascular Diseases 24. Calcium Channel Blockers 25. -Adrenoreceptor Antagonists 26. Angiotensin II Antagonists, ACE Inhibitors, and Diuretics 27. Cholesterol-Lowering Agents and Cardiac Glycosides 28. Antiarrhythmics 29. Oral Anticoagulants Treatment of Microbial Diseases 30. Oral Antifungals 31. Antivirals Treatment of Inflammation 32. H1-Receptor Antagonists 33. Analgesics-Antipyretics 34. Nonsteroidal Antiinflammatory Drugs 35. Methylxanthines Treatment of Other Diseases 36. H2-Antagonists, Proton-Pump Inhibitors, and Antiemetics 37. Immunosuppressive Agents 38. Estrogens and Progestins 39. Hypoglycemic Agents 40. Antineoplastic Agents Section IV: Drugs as Inhibitors of Metabolic Enzymes Treatment of CNS Diseases 41. Anticonvulsants 42. Antidepressants 43. Neuroleptics and Antipsychotics Treatment of Cardiovascular Diseases 44. Calcium Channel Blockers 45. Antiarrythmics Treatment of Microbial Diseases 46. Antimicrobials and Antiparasitics 47. Antifungals 48. Protease Inhibitors Treatment of Other Diseases 49. H2-Receptor Antagonists 50. Inhibitors in the Diet: Grapefruit Juice-Drug Interactions Section V: Drugs as Inducers of Metabolic Enzymes 51. Phenobarbital, Phenytoin, and Carbamazepine 52. Rifampin, Dexamethasone, and Omeprazole 53. Isoniazid and Ethanol Section VI: Clinical Considerations 54. Clinical and Pharmacoeconomic Significance of Metabolic Drug Interactions 55. Pharmacist Management of Drug Interactions 56. Interactions in the Elderly Section VII: Appendix Other Drugs Drug Interaction Index General Inde
Release date NZ
April 1st, 2000
Country of Publication
United States
163 illusrtations
Lippincott Williams and Wilkins
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