This text is the most comprehensive resource on the application of physical chemical principles in the various branches of pharmacy. It helps students, teachers, researchers, and manufacturing pharmacists use the elements of mathematics, chemistry, and physics in their work and study. This edition thoroughly examines basic physical pharmacy principles, equilibria phenomena, kinetic phenomena, dispersed systems, and drug delivery, and relates the pharmaceutical sciences to biological phenomena. New chapters cover biopharmaceutics and bioavailability; molecular and cellular biopharmaceutics; transporters and metabolizing enzymes; molding and compaction; and drug delivery systems. Significantly updated and revised review questions for each chapter are available in the book.
Table of Contents
1. Introduction Section 1: Basic Principles 2. States of Matter 3. Thermodynamics 4. Physical Properties of Drugs Section 2: Equilibria Phenomena 5. Solutions of Nonelectrolytes 6. Solutions of Electrolytes 7. Solubility and Distribution Phenomena 8. Complexation and Protein Binding Section 3: Kinetic Phenomena Mass Transport in Pharmaceutical Systems 9. Diffusion 10. Drug Release and Dissolution 11. Biopharmaceutical Aspects 12. Chemical Kinetics and Stability Section 4: Dispersed Systems 13. Interfacial Phenomena 14. Colloids 15. Coarse Dispersions Section 5: Drug Delivery 16. Micromeritics 17. Rheology 18. Biomaterials 19. Drug Delivery System
