Retaining the post-apocalyptic setting of the prequel game, KKND2 builds upon the fast and furious real-time strategy action that gamers have come to associate with the KKND games.

KKND2 adds features that increase the strategic elements of the game. These include the addition of walls to divert or slow down the enemy, destructible bridges which can vastly alter the effectiveness or focus of an opponent's attack, and 3D terrain emulation which brings height advantage into play on hills or cliffs, as well as adding realistic line-of-sight, allowing such tactics as hiding and ambushing. New terrain types - for instance the urban environment - add variety to level layouts and change the pace of the mission, and the new unit types - amphibious and aerial units - can open up areas and routes that would otherwise be inaccessible.