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IgM and Its Receptors and Binding Proteins

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Description

This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fcα/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.

Author Biography:

Hiromi Kubagawa, MD, is presently Guest Senior Scientist at Deutsches Rheuma-Forschungszentrum, Berlin, Germany  Peter D. Burrows, PhD,  is a professor at Dept. of Microbiology, University of Alabama at Birmingham, AL, USA
Release date NZ
November 3rd, 2017
Audience
  • Professional & Vocational
Contributors
  • Edited by Hiromi Kubagawa
  • Edited by Peter D. Burrows
Edition
1st ed. 2017
Illustrations
15 Illustrations, color; 15 Illustrations, black and white; IX, 117 p. 30 illus., 15 illus. in color.
Pages
117
ISBN-13
9783319645247
Product ID
26865408

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