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Harrison's Principles of Internal Medicine

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Harrison's Principles of Internal Medicine by Anthony Fauci
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This is the most widely-read and authoritative textbook in all of medicine - extensively revised and updated to meet the challenges of global medicine and enhanced with an image-packed DVD. The No. 1 selling medical textbook worldwide, "Harrison's" has defined internal medicine for millions of physicians and students worldwide since 1950. The new Seventeenth Edition retains its balance of science and patient management and has been massively updated to include an innovative array of new features and content.

Table of Contents

Contents Contributors Preface Part 1 Introduction to Clinical Medicine 1 The Practice of Medicine The Editors 2 Global Issues in Medicine Jim Yong Kim / Paul Farmer 3 Decision-Making in Clinical Medicine Daniel B. Mark 4 Screening and Prevention of Diseases Gary J. Martin 5 Principles of Clinical Pharmacology Dan M. Roden 6 Women's Health Andrea Dunaif 7 Medical Disorders during Pregnancy Robert L. Barbieri / John T. Repke 8 Medical Evaluation of the Surgical Patient Wei C. Lau / Kim A. Eagle 9 Geriatric Medicine Lisa B. Caruso / Rebecca A. Silliman 10 Complementary and Alternative Medicine Stephen E. Straus 11 Palliative and End-of-Life Care Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel e1 The Safety and Quality of Health Care David W. Bates e2 Economic Considerations in the Practice of Medicine David Meltzer e3 Racial and Ethnic Disparities in Health CareJoseph R. Betancourt / David Blumenthal e4 Ethical Issues in Clinical Medicine Bernard Lo Part 2 Cardinal Manifestations and Presentation of Diseases Section 1 Pain 12 Pain: Pathophysiology and Management Howard L. Fields / Joseph B. Martin 13 Chest Discomfort Thomas H. Lee 14 Abdominal Pain William Silen 15 Headache Peter J. Goadsby / Neil H. Raskin 16 Back and Neck Pain John W. Engstrom Section 2 Alterations in Body Temperature 17 Fever and Hyperthermia Charles A. Dinarello / Reuven Porat 18 Fever and Rash Elaine T. Kaye / Kenneth M. Kaye e5 Atlas of Rashes Associated with Fever Elaine T. Kaye / Kenneth M. Kaye 19 Fever of Unknown Origin Jeffery A. Gelfand / Michael V. Callahan 20 Hypothermia and Frostbite Daniel F. Danzl Section 3 Nervous System Dysfunction 21 Syncope Mark D. Carlson 22 Dizziness and Vertigo Robert B. Daroff 23 Weakness and Paralysis Michael J. Aminoff 24 Gait and Balance Disorders Lewis Sudarsky 25 Numbness, Tingling, and Sensory Loss Michael J. Aminoff / Arthur K.Asbury 26 Confusion and Delirium S. Andrew Josephson / Bruce L. Miller e6 Memory Loss Thomas D. Bird / Bruce L. Miller 27 Aphasia, Memory Loss, and Other Focal Cerebral Disorders M.-Marsel Mesulam 28 Sleep Disorders Charles A. Czeisler / John W. Winkleman / Gary S. Richardson Section 4 Disorders of Eyes, Ears, Nose, and Throat 29 Disorders of the Eye Jonathan C. Horton 30 Disorders of Smell, Taste, and Hearing Anil K. Lalwani 31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Infections Michael A. Rubin / Ralph Gonzales / Merle A. Sande 32 Oral Manifestations of Disease Samuel C. Durso e7 Atlas of Oral Manifestations of Disease Samuel C. Durso / Janet A. Yellowitz Section 5 Alterations in Circulatory and Respiratory Functions 33 Dyspnea and Pulmonary Edema Richard M. Schwartzstein 34 Cough and Hemoptysis Steven E. Weinberger / David A. Lipson 35 Hypoxia and Cyanosis Eugene Braunwald 36 Edema Eugene Braunwald / Joseph Loscalzo e8 Approach to the Patient with a Heart Murmur Patrick O'Gara / Eugene Braunwald 37 Palpitations Joseph Loscalzo Section 6 Alterations in Gastrointestinal Function 38 Dysphagia Raj K. Goyal 39 Nausea, Vomiting, and Indigestion William L. Hasler 40 Diarrhea and Constipation Michael Camilleri / Joseph A. Murray 41 Weight Loss Carol M. Reife 42 Gastrointestinal Bleeding Loren Laine 43 Jaundice Daniel S. Pratt / Marshall M. Kaplan 44 Abdominal Swelling and Ascites Robert M. Glickman / Roshini Rajapaksa Section 7 Alterations in Renal and Urinary Tract Function 45 Azotemia and Urinary AbnormalitiesBradley M. Denker / Barry M. Brenner e9 Atlas of Urinary Sediments and Renal Biopsies Agnes B. Fogo / Eric G. Neilsen 46 Fluid and Electrolyte Disturbances Gary G. Singer / Barry M. Brenner 47 Hypercalcemia and HypocalcemiaSundeep Khosla 48 Acidosis and Alkalosis Thomas B. DuBose, Jr. Section 8 Alterations in Sexual Function and Reproduction 49 Sexual Dysfunction Kevin T. McVary 50 Hirsutism and Virilization David A. Ehrmann 51 Menstrual Disorders and Pelvic Pain Janet E. Hall Section 9Alterations in the Skin 52 Approach to the Patient with a Skin Disorder Thomas J. Lawley / Kim B. Yancey 53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders Calvin O. McCall / Thomas J. Lawley 54 Skin Manifestations of Internal DiseaseJean L. Bolognia / Irwin M. Braverman 55 Immunologically Mediated Skin Diseases Kim B. Yancey / Thomas J. Lawley 56 Cutaneous Drug ReactionsJean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub 57 Photosensitivity and Other Reactions to Light David R. Bickers e10 Atlas of Skin Manifestations of Internal Disease Thomas J. Lawley / Stephen Templeton Section 10 Hematologic Alterations 58 Anemia and Polycythemia John W. Adamson / Dan L. Longo 59 Bleeding and Thrombosis Barbara A. Konkle 60 Enlargement of Lymph Nodes and Spleen Patrick H. Henry / Dan L. Longo 61 Disorders of Granulocytes and Monocytes Steven M. Holland /John I. Gallin e11 Atlas of Hematology and Analysis of Peripheral Blood Smears Dan L. Longo Part 3Genetics and Disease 62 Principles of Human Genetics J. Larry Jameson / Peter Kopp 63 Chromosome Disorders Terry Hassold / Stuart Schwartz 64 The Practice of Genetics in Clinical Medicine Susan Miesfeldt / J. Larry Jameson 65 Gene Therapy in Clinical MedicineKatherine A. High Part 4 Regenerative Medicine 66 Stem Cell Biology Minoru S. H. Ko 67 Applications of Stem Cell Biology in Clinical Medicine Jack A. Kessler 68 Hematopoietic Stem Cells David T. Scadden / Dan L. Longo 69 Tissue Engineering Jennifer Anderson /Joseph P. Vacanti Part 5 Nutrition 70 Nutritional Requirements and Dietary Assessment Johanna Dwyer 71 Vitamin and Trace Mineral Deficiency and Excess Robert M. Russell / Paolo M. Suter 72 Malnutrition and Nutritional Assessment Douglas C. Heimburger 73 Enteral and Parenteral Nutrition Therapy Bruce R. Bistrian / David F. Driscoll 74 Biology of Obesity Jeffrey S. Flier / Eleftheria Maratos-Flier 75 Evaluation and Management of Obesity Robert F. Kushner 76 Eating Disorders B. Timothy Walsh Part 6 Oncology and Hematology Section 1 Neoplastic Disorders 77 Approach to the Patient with Cancer Dan L. Longo 78 Prevention and Early Detection of Cancer Otis W. Brawley / Barnett S. Kramer 79 Cancer Genetics Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein 80 Cancer Cell Biology and Angiogenesis Robert G. Fenton / Dan L. Longo 81 Principles of Cancer Treatment Edward A. Sausville / Dan L. Longo 82 Infections in Patients with Cancer Robert Finberg 83 Cancer of the Skin Arthur J. Sober / Hensin Tsao / Carl V. Washington 84 Head and Neck Cancer Everett E. Vokes 85 Neoplasms of the Lung John D. Minna / Joan H. Schiller 86 Breast Cancer Marc E. Lippman 87 Gastrointestinal Tract Center Robert J. Mayer 88 Tumors of the Liver and Biliary Tree Brian I. Carr 89 Pancreatic Cancer Yu Jo Chua / David Cunningham 90 Bladder and Renal Cell Carcinomas Howard I. Scher / Robert J. Motzer 91 Benign and Malignant Diseases of the Prostate Howard I. Scher 92 Testicular Cancer Robert J. Motzer / George J. Bosl 93 Gynecologic Malignancies Robert C. Young 94 Soft Tissue and Bone Sarcomas and Bone Metastases Shreyaskumar R. Patel / Robert S. Benjamin 95 Carcinoma of Unknown Primary Gauri R. Varadhachary /James L. Abbruzzese 96 Paraneoplastic Syndromes: Endocrinologic/Hematologic J. Larry Jameson / Bruce E. Johnson 97 Paraneoplastic Neurologic Syndromes Joseph Dalmau / Myrna R. Rosenfeld e12 Thymoma Dan L. Longo e13 Late Consequences of Cancer and Its Treatment Michael C. Perry / Dan L. Longo Section 2 Hematopoietic Disorders 98 Iron Deficiency and Other Hypoproliferative Anemias John W. Adamson 99 Disorders of Hemoglobin Edward J. Benz 100 Megaloblastic Anemia A. Victor Hoffbrand 101 Hemolytic Anemias and Anemias due to Acute Blood Loss Lucio Luzzatto 102 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes Neal S. Young 103 Polycythemia Vera and Other Myeloproliferative Diseases Jerry L. Spivak 104 Acute and Chronic Myeloid Leukemia Meir Wetzler /John C. Byrd / Clara D. Bloomfield 105 Malignancies of Lymphoid Cells Dan L. Longo 106 Plasma Cell Disorders Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson 107 Transfusion Biology and Therapy Jeffery S. Dzieczkowski / Kenneth C. Anderson 108 Hematopoietic Cell Transplantation Frederick R. Applebaum Section 3 Disorders of Hemostasis 109 Disorders of Platelets and Vessel Wall Barbara A. Konkle 110 Coagulation Disorders Valder Arruda / Katherine High 111 Thrombosis Venous F.R. Rosendaal / H.R. Buller 112 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs Jeffery L. Weitz Part 7 Infectious Diseases Section 1 Basic Considerations in Infectious Diseases 113 Introduction to Infectious Diseases: Host-Pathogen Interactions Lawrence C. Madoff / Dennis L. Kasper 114 Molecular Mechanisms of Microbial Pathogenesis Gerald B. Pier 115 Approach to the Acutely Ill Infected Febrile Patient Tamar F. Barlam / Dennis L. Kasper 116 Immunization Principles and Vaccine Use Gerald T. Keusch / Kenneth J. Bart / Mark Miller 117 Health Advice for International Travel J.S. Keystone / P.E. Kozarsky e14 Laboratory Diagnosis of Infectious Diseases Alexander J. McAdam / Andrew B. Onderdonk Section 2 Clinical Syndromes: Community-Acquired Infections 118 Infective Endocarditis Adolf W. Karchmer 119 Infections of the Skin, Muscle, and Soft Tissues Dennis L. Stevens 120 Osteomyelitis Jeffrey Parsonnet 121 Intraabdominal Infections and Abscesses Miriam J. Baron / Dennis L. Kasper 122 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning Joan R. Butterton / Stephen B. Calderwood 123 Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis Dale N. Gerding / Stuart Johnson 124 Sexually Transmitted Infections: Overview and Clinical Approach King K. Holmes e15 Infectious Complications of Bites and Burns Lawrence C. Madoff / Florencia Pereyra Section 3 Clinical Syndromes: Nosocomial Infections 125 Health Care-Associated Infections Robert A. Weinstein 126 Infections in Transplant Recipients Robert Finberg /Joyce Fingeroth Section 4 Approach to Therapy for Bacterial Diseases 127 Treatment and Prophylaxis of Bacterial Infections Gordon L. Archer / Ronald E. Polk Section 5 Diseases Caused by Gram-Positive Bacteria 128 Pneumococcal Infections Daniel M. Musher 129 Staphylococcal Infections Franklin D. Lowy 130 Strepococcal and Enterococcal Infections Michael R. Wessels 131 Diphtheria and Other Infections Caused by Corynebacteria and Related Species William R. Bishai / Jack R. Murphy 132 Infections Caused by Listeria monocytogenes Elizabeth L. Hohmann / Daniel A. Portnoy 133 Tetanus Elias Abrutyn 134 Botulism Elias Abrutyn 135 Gas Gangrene and Other Clostridial Infections Dennis L. Kasper /Lawrence C. Madoff Section 6 Diseases Caused by Gram-Negative Bacteria 136 Meningococcal Infections Lee M. Wetzler 137 Gonococcal Infections Sanjay Ram / Peter A. Rice 138 Moraxella Infections Daniel M. Musher 139 Haemophilus Infections Timothy F. Murphy 140 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria Tamar F. Barlam / Dennis L. Kasper 141 Legionella Infection Miguel Sabria / Victor L. Yu 142 Pertussis and Other Bordetella Infections Scott A. Halperin 143 Diseases Caused by Gram-Negative Enteric Bacilli Thomas A. Russo / James R. Johnson 144 Helicobacter Pylori Infections John C. Atherton / Martin J. Blaser 145 Infections Due to Pseudomonas Species and Related Organisms Reuben Ramphal 146 Salmonellosis David A. Pegues / Samuel I. Miller 147 Shingellosis Philippe Sansonetti / Jean Bergounioux 148 Infections Due to Campylobacter and Related Species Martin J. Blaser 149 Cholera and Other Vibrioses Matthew K. Waldor / Gerald T. Keusch 150 Brucellosis Michael J. Corbel / Nicholas J. Beeching 151 Tularemia Richard F. Jacobs / Gordon E. Schutze 152 Plague and Other Yersnia Infections David T. Dennis / Grant L. Campbell 153 Bartonella Infections, Including Cat-Scratch Disease David H. Spach / Emily Darby 154 Donovanosis Gavin Hart Section 7 Miscellaneous Bacterial Infections 155 Nocardiosis Gregory A. Filice 156 Actinomycosis Thomas A. Russo 157 Infections Due to Mixed Anaerobic Organisms Dennis L. Kasper / Ronit Cohen-Poradosu Section 8 Mycobacterial Diseases 158 Tuberculosis Mario C. Raviglione / Richard J. O'Brien 159 Leprosy (Hansen's Disease) Robert H. Gelber 160 Nontuberculous Mycobacteria C. Fordham von Reyn 161 Antimycobacterial Agents Richard J. Wallace / David E. Griffith Section 9Spirochetal Disease 162 Syphilis Sheila A. Lukehart 163 Endemic Treponematoses Sheila A. Lukehart 164 Leptospirosis Peter Speelman / Rudy Harkskeerl 165 Relapsing Fever David T. Dennis 166 Lyme Borreliosis Allen C. Steere Section 10Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia 167 Rickettsial Diseases David H. Walker / J. Stephen Dumler / Thomas Marrie 168 Infections Due to Mycoplasmas William M. McCormack 169 Chlamydial Infections Walter E. Stamm Section 11 Viral Diseases: General Considerations 170 Medical Virology Fred Wang /Elliott Kieff 171 Antiviral Chemotherapy, Excluding Antiretroviral Drugs Lindsey R. Baden / Raphael Dolin Section 12 Infections Due to DNA Viruses 172 Herpes Simplex Viruses Lawrence Corey 73 Varicella-Zoster Virus Infections Richard J. Whitley 174 Epstein-Barr Virus Infections, Including Infectious Mononucleosis Jeffery I. Cohen 175 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 Martin S. Hirsch 176 Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox Virus Fred Wang 177 Parvovirus Infections Kevin E. Brown 178 Human Papillomavirus Infections Richard C. Reichman Section 13 Infections Due to DNA and RNA Respiratory Viruses 179 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS) Raphael Dolin 180 Influenza Raphael Dolin Section 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses 181 The Human Retroviruses Dan L. Longo /Anthony S. Fauci 182 Human Immunodeficiency Virus Disease: AIDS and Related Disorders Anthony S. Fauci / H. Clifford Lane Section 15 Infections Due to RNA Viruses 183 Viral Gastroenteritis Umesh D. Parashar / Roger I. Glass 184 Enterovirus and Reoviruses Infections Jeffery I. Cohen 185 Measles (Rubeola) Anne Gershon 186 Rubella (German Measles) Anne Gershon 187 Mumps Anne Gershon 188 Rabies and Other Rhabdovirus Infections Alan C. Jackson / Eric C. Johannsen 189 Infections Caused by Arthropod and Rodent-Borne Viruses Clarence J. Peters 190 Ebola and Marburg Viruses Clarence J. Peters Section 16 Fungal and Algal Infections 191 Diagnosis and Treatment of Fungal Infections John E. Edwards 192 Histoplasmosis Chadi A. Hage / L. Joseph Wheat 193 Coccidioidomycosis Neil M. Ampel 194 Blastomycosis Stanley W. Chapman 195 Cryptococcosis Arturo Casadevall 196 Candidiasois John E. Edwards 197 Aspergillosis David W. Denning 198 Mucormycosis Alan M. Sugar 199 Miscellaneous Mycoses and Algal Infections Stanley W. Chapman / Donna C. Sullivan 200 Pneumocystis Infection A. Geroge Smulian /Peter D. Walzer Section 17 Protozoal and Helminthic Infections: General Considerations e16 Laboratory Diagnosis of Parasitic Infections Sharon L. Reed / Charles E. Davis 201 Agents Used to Treat Parasitic Infections Thomas A. Moore e17 Pharmacology of Agents Used to Treat Parasitic Infections Thomas A. Moore Section 18 Protozoal Infections 202 Ambiasis and Infection with Free-Living Amebas Sharon L. Reed 203 Malaria Nicholas J. White / Joel G. Breman 204 Babesiosis Jeffery Gelfand e18 Atlas of Blood Smears of Malaria and Babesiosis Nicholas J. White / Joel G. Breman 205 Leishmaniasis Barbara L. Herwaldt 206 Trypanosomiasis Louis V. Kirchhoff 207 Toxoplasma Infections Lloyd H. Kasper 208 Protozoal Intestinal Infections and Trichomoniasis Peter F. Weller Section 19 Helminthic Infections 209 Trichinella and Other Tissue Nematodes Peter F. Weller 210 Intestinal Nematodes Peter F. Weller /Thomas B. Nutman 211 Filarial and Related Infections Peter F. Weller / Thomas B. Nutman 212 Schistosomiasis and Other Trematode Infections Adel A.F. Mahmoud 213 Cestodes A. Clinton White, Jr. / Peter F. Weller Part 8 Bioterrorism and Clinical Medicine 214 Microbioterrorism H. Clifford Lane / Anthony S. Fauci 215 Chemical Bioterrorism Charles G. Hurst / Jonathan Newmark / James A. Romano 216 Radiation Bioterrorism Zelig A. Tochner / Eli Glatstein Part 9 Disorders of Cardiovascular System Section 1 Introduction to Cardiovascular Disorders 217 Basic Biology of the Cardiovascular System Joseph Loscalzo / Peter Libby / Eugene Braunwald 218 Epidemiology of Cardiovascular Disease Thomas A. Gaziano / J. Michael Gaziano 219 Approach to the Patient with Possible Cardiovascular Disease Eugene Braunwald Section 2 Diagnosis of Cardiovascular Disorders 220 Physical Examination of the Cardiovascular System Robert A. O'Rourke /Eugene Braunwald 221 Electrocardiography Ary L. Goldberger e19 Atlas of Electrocardiography Ary L. Goldberger 222 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging Rick Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik e20 Atlas of Noninvasive Cardiac Imaging Rick Nishimura 223 Diagnostic Cardiac Catheterization and Angiography Donald S. Baim Section 3 Disorders of Rhythm 224 Principles of Electrophysiology Gordon F. Tomaselli 225 The Bradyarrhythmias Gordon F. Tomaselli 226 The Tachyarrhythmias Francis Marchlinksi e21 Atlas of Cardiac Arrhythmias Ary L. Goldberger Section 4 Disorders of the Heart 227 Heart Failure and Cor Pulmonale Douglas L. Mann 228 Cardiac Transplantation and Prolonged Assisted Circulation Sharon A. Hunt 229 Congenital Heart Disease in the Adult John S. Child 230 Valvular Heart Disease Patrick O'Gara / Eugene Braunwald 231 Cardiomyopathy and Myocarditis Joshua Wynne / Eugene Braunwald 232 Pericardial Disease Eugene Braunwald 233 Tumors and Trauma of the Heart Eric H. Awtry / Wilson S. Colucci 234 Cardiac Manifestations of Systemic Disease Eric H. Awtry / Wilson S. Colucci Section 5 Vascular Disease 235 The Pathogenesis, Prevention, and Treatment of Atherosclerosis Peter Libby e22 Atlas of Atherosclerosis Peter Libby 236 The Metabolic Syndrome Robert H. Eckel 237 Ischemic Heart Disease Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo 238 Unstable Angina and Non-ST-Elevation Myocardial Infarction Christopher P. Cannon / Eugene Braunwald 239 ST-Segment Elevation Myocardial Infarction Elliott M. Antman / Eugene Braunwald 240 Percutaneous Coronary Intervention Donald S. Baim e23 Atlas of Percutaneous Revascularization Donald S. Baim 241 Hypertensive Vascular Disease Ted A. Kotchen 242 Diseases of the Aorta Mark A. Creager / Joseph Loscalzo 243 Vascular Diseases of the Extremities Mark A. Creager / Joseph Loscalzo 244 Pulmonary Hypertension Stuart Rich Part 10 Disorders of the Respiratory System Section 1 Diagnosis of Respiratory Disorders 245 Approach to the Patient with Disease of the Respiratory System David A. Lipson / Steven E. Weinberger 246 Disturbances of Respiratory Function Steven E. Weinberger /Ilene M. Rosen 247 Diagnostic Procedures in Respiratory Diseases Scott Manaker / Steven E. Weinberger e24 Atlas of Chest Imaging Patricia Kritek / John J. Reilly, Jr. Section 2 Diseases of the Respiratory System 248 Asthma Peter J. Barnes 249 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia Joel N. Kline / Gary W. Hunninghake 250 Environmental Lung Disease Frank E. Speizer / John R. Balmes 251 Pneumonia Lionel A. Mandell / Richard Wunderink 252 Bronchiectasis and Lung Abscess Gregory Tino / Steven E. Weinberger 253 Cystic Fibrosis Richard C. Boucher 254 Chronic Obstructive Pulmonary Disease John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro 255 Interstitial Lung Diseases Talmadge E. King, Jr. 256 Deep Venous Thrombosis and Pulmonary Thromboembolism Samuel Z. Goldhaber 257 Disorders of the Pleura and Mediastinum Richard W. Light 258 Disorders of Ventilation Eliot A. Phillipson 259 Sleep Apnea Neil J. Douglas 260 Lung Transplantation Elbert P. Trulock Part 11 Critical Care Medicine Section 1 Respiratory Critical Care 261 Principles of Critical Care Medicine John P. Kress / Jesse B. Hall 262 Acute Respiratory Distress Syndrome Bruce D. Levy / Steve D. Shapiro 263 Mechanical Ventilatory Support Edward P. Ingenito Section 2 Shock and Cardiac Arrest 264 Approach to the Patient with Shock Ronald V. Maier 265 Severe Sepsis and Septic Shock Robert S. Munford 266 Cardiogenic Shock and Pulmonary Edema Judith S. Hochman / David H. Ingbar 267 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death Robert J. Myerberg / Agustin Castellanos Section 3 Neurologic Critical Care 268 Coma Allan H. Ropper 269 Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage J. Claude Hemphill / Wade S. Smith Section 4 Oncologic Emergencies 270 Oncologic Emergencies Rasim Gucalp / Janice Dutcher Part 12 Disorders of the Kidney and Urinary Tract 271 Cellular and Molecular Biology of the Kidney Alfred L. George / Eric G. Neilson 272 Adaptation of the Kidney to Renal Injury Raymond C. Harris / Eric G. Neilson 273 Acute Renal Failure Kathleen D. Liu / Glenn M. Chertow 274 Chronic Kidney Disease Joanne M. Bargman / Karl Skorecki 275 Dialysis in the Treatment of Renal Failure Kathleen D. Liu / Glenn M. Chertow 276 Transplantation in the Treatment of Renal Failure Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh 277 Glomerular Diseases Julia B. Lewis / Eric G. Neilson 278 Polycystic Kidney Disease and Other Inherited Tubular Disorders David J. Salant / Parul S. Patel 279 Tubulointerstitial Diseases of the Kidney Alan S. L. Yu / Barry M. Brenner 280 Vascular Injury to the Kidney Kamal F. Badr / Barry M. Brenner 281 Nephrolithiasis John R. Asplin / Fredric L. Coe / Murray J. Favus 282 Urinary Tract Infections, Pyelonephritis, and Prostatitis Walter E. Stamm 283 Urinary Tract Obstruction Julian L. Seifter / Barry M. Brenner Part 13 Disorders of the Gastrointestinal System Section 1 Disorders of the Alimentary Tract 284 Approach to the Patient with Gastrointestinal Disease William L. Hasler / Chung Owyang 285 Gastrointestinal Endoscopy Louis Michel Wong Kee Song / Mark Topazian e25 Video Atlas of Gastrointestinal Endoscopy Mark Topazian 286 Diseases of the Esophagus Raj. K. Goyal 287 Peptic Ulcer Disease and Related Disorders John Del Valle 288 Disorders of Absorption Henry J. Binder 289 Inflammatory Bowel Disease Sonia Friedman / Richard S. Blumberg 290 Irritable Bowel Syndrome Chung Owyang 291 Diverticular Disease and Common Anorectal Disorders Susan L. Gearhart 292 Mesenteric Vascular Insufficiency Susan L. Gearhart 293 Acute Intestinal Obstruction Susan L. Gearhart / William Silen 294 Acute Appendicitis and Peritonitis Susan L. Gearhart / William Silen Section 2 Liver and Biliary Tract Disease 295 Approach to the Patient with Liver Disease Marc Ghany /Jay H. Hoofnagle 296 Evaluation of Liver Function Daniel S. Pratt / Marshall M. Kaplan 297 The Hyperbilirubinemias Allan W. Wolkoff 298 Acute Viral Hepatitis Jules L. Dienstag 299 Toxic and Drug-Induced Hepatitis Jules L. Dienstag 300 Chronic Hepatitis Jules L. Dienstag 301 Alcoholic Liver Disease Mark E. Malliard / Michael F. Sorrell 302 Cirrhosis and Its Complications Bruce R. Bacon e26 Atlas of Liver Biopsies Jules L. Dienstag / Atul K. Bhau 303 Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver Bruce R. Bacon 304 Liver Transplantation Jules L. Dienstag /Raymond T. Chung 305 Diseases of the Gallbladder and Bile Ducts Norton J. Greenberger / Gustav Paumgartner Section 3 Disorders of the Pancreas 306 Approach to the Patient with Pancreatic Disease Phillip P. Toskes / Norton J. Greenberger 307 Acute and Chronic Pancreatitis Norton J. Greenberger / Phillip P. Toskes Part 14 Disorders of the Immune System, Connective Tissue, and Joints Section 1 The Immune System in Health and Disease 308 Introduction to the Immune System Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci 309 The Major Histocompatability Complex Gerald T. Nepom 310 Primary Immune Deficiency Diseases Max D. Cooper / Harry W. Schroeder, Jr. e27 Primary Immunodeficiencies Associated with or Secondary to Other Diseases Max D. Cooper Section 2 Disorders of Immune-Mediated Injury 311 Allergies, Anaphylaxis, and Systemic Mastocytosis K. Frank Austen 312 Autoimmunity and Autoimmune Diseases Peter E. Lipsky / Betty Diamond 313 Systemic Lupus Erythematosus Bevra Hannahs Hahn 314 Rheumatoid Arthritis Peter E. Lipsky 315 Acute Rheumatoid Fever Jonathan R. Carapetis 316 Systemic Sclerosis (Scleroderma) and Related Disorders John Varga 317 Sjogren's Syndrome Haralampos M. Moutsopoulos 318 The Spondyloarthritides Joel D. Taurog 319 The Vasculitis Syndromes Carol A. Langford / Anthony S. Fauci e28 Atlas of Clinical Imaging of the Vasculitic Diseases Carol A. Langford / Anthony S. Fauci 320 Behcet's Syndrome Haralampos M. Moutsopoulos 321 Relapsing Polychondritis Carol A. Langford /Bruce C. Gilliland 322 Sarcoidosis Robert P. Baughman /Elyse E. Lower 323 Familial Mediterranean Fever and Other Hereditary Recurrent Fevers Daniel L. Kastner 324 Amyloidosis David C. Seldin / Martha Skinner Section 3 Disorders of the Joints and Adjacent Tissues 325 Approach to Articular and Musculoskeletal Disorders John J. Cush / Peter E. Lipsky 326 Osteoarthritis David T. Felson 327 Gout and Other Crystal Arthropathies H. Ralph Schumacher / Lan X. Chen 328 Infectious Arthritis Lawrence C. Madoff 329 Fibromyalgia Carol A. Langford /Bruce C. Gilliland 330 Arthritis Associated with Systemic Disease and Other Arthritides Carol A. Langford / Bruce C. Gilliland 331 Periarticular Disorders of the Extremities Carol A. Langford / Bruce C. Gilliland Part 15 Endocrinology and Metabolism Section 1 Endocrinology 332 Principles of Endocrinology J. Larry Jameson 333 Disorders of the Anterior Pituitary and Hypothalamus Shlomo Melmed / J. Larry Jameson 334 Disorders of the Neurohypophysis Gary L. Robertson 335 Disorders of the Thyroid Gland J. Larry Jameson / Anthony P. Weetman 336 Disorders of the Adrenal Cortex Gordon H. Williams / Robert G. Dluhy 337 Pheochromocytoma Hartmut P.H. Neumann 338 Diabetes Mellitus Alvin C. Powers 339 Hypoglycemia Phillip E. Cryer 340 Disorders of the Testes and the Male Reproductive System Shalender Bhasin / J. Larry Jameson 341 Disorders of the Ovary and Female Reproductive Tract Janet E. Hall 342 The Menopause Transition and Postmenopausal Hormone Therapy JoAnn E. Manson /Shari S. Bassuk 343 Disorders of Sex Development John C. Achermann / J. Larry Jameson 344 Endocrine Tumors of the Gastrointestinal Tract and Pancreas Robert T. Jensen 345 Disorders Affecting Multiple Endocrine Neoplasia Syndromes Camillo Jimenez / Robert Gagel Section 2 Disorders of Bone and Mineral Metabolism 346 Bone and Mineral Metabolism in Health and Disease F. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg 347 Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemia Disorders John T. Potts, Jr. 348 Osteoporosis Robert Lindsay / Felicia Cosman 349 Paget Disease and Other Dysplasias of Bone Murray J. Favus /Tamara J. Vokes Section 3 Disorders of Intermediary Metabolism 350 Disorders of Lipoprotein Metabolism Daniel J. Rader / Helen H. Hobbs 351 Hemochromatosis Lawrie W. Powell 352 The Porphyrias Robert J. Desnik / Kenneth H. Astrin 353 Disorders of Purine and Pyrimidine Metabolism Robert L. Wortmann 354 Wilson Disease George J. Brewer 355 Lysosomal Storage DiseaseRobert J. Hopkin / Gregory A. Grabowski 356 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism Yuan-Tsong Chen 357 Heritable Disorders of Connective Tissue Darwin J. Prockop / Malwina Czarny-Ratajczak 358 Inherited Disoders of Amino Acid Metabolism in Adults Nicola Longo 359 Inherited Defects of Membrane Transport Nicola Longo e29 Atlas of Clinical Manifestations of Metabolic Diseases J. Larry Jameson Part 16 Neurologic Disorders Section 1 Diagnosis of Neurologic Disorders 360 Mechanisms of Neurologic Disorders Stephen Hauser / M. Flint Beal 361 Approach to the Patient with Neurologic Disease Daniel H. Lowenstein / Joseph B. Martin / Stephen L. Hauser 362 Neuroimaging in Neurologic Disorders William P. Dillon e30 Atlas of Neuroimaging Andre Furtado / William P. Dillon e31 Electrodiagnostic Studies of Nervous System Disorders: EEG and EMG Michael J. Aminoff e32 Technique of Lumbar Puncture Elizabeth Robbins / Stephen L. Hauser Section 2 Diseases of the Central Nervous System 363 Seizures and Epilepsy Daniel H. Lowenstein 364 Cerebrovascular Diseases Wade S. Smith / Joey English / S. Claiborne Johnston 365 Dementia Thomas D. Bird / Bruce L. Miller 366 Parkinson's Disease and Other Extrapyramidal Disorders Mahlon R. DeLong / Jorge L. Juncos 367 Hyperkinetic Movement Disorders C. Warren Olanow 368 Ataxic Disorders Roger N. Rosenberg 369 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Robert H. Brown, Jr. 370 Disorders of the Autonomic Nervous System Phillip A. Low / John W. Engstrom 371 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders M. Flint Beal / Stephen L. Hauser 372 Diseases of the Spinal Cord Stephen L. Hauser / Allan H. Ropper 373 Concussion and Other Head Injuries Allan H. Ropper 374 Primary and Metastatic Tumors of the Nervous System Stephen M. Sagar / Mark A. Israel 375 Multiple Sclerosis and Other Demyelinating Diseases Stephen L. Hauser / Douglas S. Goodin 376 Meningitis, Encephalitis, Brain Abscess,and Empyema Karen L. Roos / Kenneth L. Tyler 377 Chronic and Recurrent Meningitis Walter J. Koroshetz / Morton N. Swartz 378 Prion Diseases Stanley B. Prusiner / Bruce L. Miller Section 3 Nerve and Muscle Disorders 379 Peripheral Neuropathy Vinay Chaudhry 380 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies Steven L. Hauser / Arthur K. Asbury 381 Mysathenia Gravis and Other Diseases of the Neuromuscular Junction Daniel B. Drachman 382 An Approach to Muscular Dystrophy and Other Muscle Diseases Robert H. Brown, Jr. / Anthony A. Amato / Jerry R. Mendell 383 Polymyositis, Dermatomyositis, and Inclusion Body Myositis Marinos C. Dalakas e33 Special Issues in Inpatient Neurologic Consultation S. Andrew Josephson / Martin A. Samuels Section 4 Chronic Fatigue Syndrome 384 Chronic Fatigue Syndrome Stephen E. Straus Section 5 Psychiatric Disorders 385 Biology of Psychiatric Disorders Steve Hyman / Eric Kandel 386 Mental Disoders Victor I. Reus Section 6 Alcoholism and Drug Dependency 387 Alcohol and Alcoholism Marc A. Schuckit 388 Opioid Drug Abuse and Dependence Mark A. Schuckit 389 Cocaine and Other Commonly Abused Drugs Jack H. Medelson / Nancy K. Mello 390 Nicotine Addiction David M. Burns Part 17 Poisoning, Drug Overdose, and Envenomation e34 Heavy Metal Poisoning Howard Hu e35 Poisoning and Drug Overdosage Christopher H. Linden / Michael J. Burns / Mark B. Mycyk 391 Disorders Caused by Reptile Bites and Marine Animal Exposures Paul Auerbach / Robert Norris e36 Ectoparasite Infestations and Arthropod Bites and Stings Richard J. Pollack / James H. Maguire International e Chapters e37 Pulmonary Biomarkers in COPD Peter J. Barnes e38 Chagas' Disease: Recent Advances in Diagnosis and Management Andrei C. Sposito / Jose A.F. Ramires Summaries of Chapters e1 to e36 Appendix Laboratory Values of Clinical Importance Alexander Kratz / Michael A. Pesce / Daniel J. Fink Index

Author Biography

Anthony S. Fauci, MD, National Institute of Health, Betheseda, MD. Eugene Braunwald, MD, Harvard Medical School, Boston, MA. Dennis L. Kasper, MD, Harvard Medical School, Boston, MA. Stephen L. Hauser, MD, University of California, San Francisco, CA. Dan L. Longo, MD, National Institute of Health, Betheseda, MD. J. Larry Jameson, MD, PhD, Northwestern University, Feinberg School of Medicine, Chicago, IL. Joseph Loscalzo, MD, PhD, Harvard Medical School, Boston, MA.
Release date NZ
March 1st, 2008
Country of Publication
United States
17th Revised edition
Illustrations (chiefly col.)
McGraw Hill Higher Education
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