Genome analysis has undergone a period of explosive growth in recent years. This book describes up-to-date methods for genome mapping, arranged in order of increasing resolution, from linkage analysis to restriction mapping. Topics covered include linkage mapping of human, animal, and plant genomes; mapping of quantitative trait loci; radiation hybrid mapping; HAPPY mapping; somatic cell hybrids; flow-sorted and microdissected chromosomes; fluorescence in situ hybridization; contig assembly; chromosome walking; and long-range restriction mapping. Two appendices describe sources of freely available biological and computational resources relevant to genome analysis.
Author Biography
Dr Paul Dear, MRC Centre, Hills Road, Cambridge CB2 2QH. Email: phd@mrc-lmb.cam.ac.uk. Tel: 01223 402190. Fax: 01223 412178
