Genetic Analysis of Complex Disease, Second Edition provides a comprehensive introduction to the various strategies, designs, and methods of analysis for the study of human genetic disease. It offers a broad--based understanding of the problems and solutions based on successful applications in the design and execution of gene mapping projects. Chapters present clear and easily referenced overviews of the broad range of considerations involved in genetic analysis of human genetic disease, including design, sampling, data collection, linkage and association studies, and social, legal, and ethical issues. Incorporating all new discussion questions and practical examples within each chapter, the book significantly updates treatment of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case--control and family based approaches, and genomic screening. It covers new methods for analysis of gene--gene and gene--environmental interactions, and features a complete rewrite of the chapter on determining genetic components of disease.
New material includes chapters covering molecular genomic approaches such as microarray and SAGE analyses using single nucleotide polymorphism (SNP) and cDNA expression data, as well as quantitative trait loci (QTL) mapping. A work intended for researchers in disciplines spanning biology, genetics, and medicine, it emphasizes concepts and design rather than narrowly focusing on technical details or particular methodologies.
JONATHAN L. HAINES is Director of the Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine. His research into the localization and identification of genes involved in human disease includes studying Alzheimer's disease, multiple sclerosis, Parkinson's disease, autism, macular degeneration, and other complex diseases. MARGARET A. PERICAK-VANCE is Director of the Center for Human Genetics and Chief of the Section of Medical Genetics in the Department of Medicine, Duke University School of Medicine. She is a founding Fellow of the American College of Medical Genetics. Her research interests include the integration of genomic and statistical technologies and their application to diseases of importance to public health, with an emphasis on neurologic diseases.