Dentin hypersensitivity is a common problem observed in clinical practice. Dentine hypersensitivity is characterized by pain derived from exposed dentine in response to chemical, thermal, tactile or osmotic stimuli which cannot be explained as arising from any other dental defect or pathology. Dental professionals have a variety of regimens to manage patient dentinal hypersensitivity, including both in-office treatments and patient-applied products for home use. The aim of this research was the assessment of GC Tooth Mousse (CPP-ACP) effectiveness in the treatment of dentin hypersensitivity due to various factors and comparing it with the efficacy of KNO3 dentifrice. The results of the present clinical study suggest that there was general decrease in the dentinal hypersensitivity levels in both the 5% Potassium nitrate and CPP-ACP Group over the 6 weeks study period as demonstrated by both the assessment methods (Tactile and Air stimuli). In the both the groups patients who initially reported sensitivity, after application of the medicaments, later reported significant relief in their symptoms in just 4 and 6 weeks period.