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Drug Resistance in Epilepsy

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Drug Resistance in Epilepsy

Lessons from Oncology



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Drug Resistance in Epilepsy
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Drug resistance in epilepsy is an important clinical problem. About 30 per cent of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This book brings together epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Bridging the two fields, the discussions contained in this book should be of interest to those working on cancer resistance and refractory epilepsy alike.
Release date NZ
March 25th, 2002
Edited by Gregory R. Bock Edited by Jamie A. Goode
Country of Publication
United Kingdom
John Wiley & Sons Ltd
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