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DJ-1/PARK7 Protein

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DJ-1/PARK7 Protein

Parkinson's Disease, Cancer and Oxidative Stress-Induced Diseases

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DJ-1/PARK7 Protein
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This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson's disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.

Author Biography

Hiroyoshi Ariga Faculty of Pharmaceutical Sciences, Hokkaido University Sapporo, Japan Sanae M.M. Iguchi-Ariga Faculty of Agriculture, Hokkaido UniversitySapporo,Japan
Release date NZ
December 4th, 2017
Edited by Hiroyoshi Ariga Edited by Sanae M. M. Iguchi-Ariga
Country of Publication
1st ed. 2017
46 Illustrations, color; 32 Illustrations, black and white; VIII, 222 p. 78 illus., 46 illus. in color.
Springer Verlag, Singapore
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