Born with an extraordinary mind, Dexter has built his very own extremely high tech and expansive laboratory in his room that NASA could only dream of. All Dexter wants is to spend all the time he can inventing new things in his lab, but with his stupid and annoying older sister Dee Dee constantly barging into his lab and tearing up the place and arch-enemy/rival genius Mandark around, Dexter's life is anything but easy.