* This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D).* Brings together contributions from the leaders in the arena of clinical immunotherapy, not limited to the diabetes field exclusively, in order to delineate a road-map that would lead to future clinical trials.* The book integrates information from human and animal studies.* The book considers T1D within the broader context of autoimmune disease.* The format contains several discussions, which address specific questions and provides guidelines for future strategies and solutions for discovering a cure.