Non-Fiction Books:

Concepts in Genetic Medicine

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Hardback

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Concepts in Genetic Medicine
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Description

Concepts in Genetic Medicine offers a coherent collection of uniformly organized short reviews in the field of therapeutic genetic medicine. Each chapter focuses on a current topic ('concept') to elucidate issues in development of genetic treatments for discuses, presenting critical challenges, strategies for addressing them, and future directions.

Table of Contents

Introduction. Chapter 1: The Evolution of Human Gene Therapy. A Journey from Excessive Hype to Excessive Diffidence to Realty.(Theodore Friedmann). Delivery Systems. Chapter 2: Murine Leukemia Virus Based Vectors.(Kenneth Cornetta). Chapter 3: Lentivirus Vectors (Gwendolyn K. Binder and Boro Dropulic). Chapter 4: Adenoviral Vectors: History and Perspective (Douglas J. Jolly, Estuardo Aguilar-Cordova, and Laura K. Aguilar). Chapter 5: Adeno-associated Virus Vectors (Barrie J. Carter). Chapter 6: The Glass is Half Full: the Goal of Long-term delivery may be Approachable Using SV40-derived Vectors (David S. Strayer). Chapter 7: Herpes Simplex Virus Vectors (Anna-Marie Anesti and Robert S. Coffin). Chapter 8: Nonviral Gene Delivery Systems (Takeshi Suda and Dexi Liu). Applications. Chapter 9: Therapeutic Gene Transfer to Skeletal Muscle (Paul Gregorevic and Jeffrey S. Chamberlain). Chapter 10: Gene Therapy for Cardiovascular Disease (Christina A. Pacak, Kerry O. Cresawn, and Barry J. Byrne). Chapter 11: Intra-articular Vector Delivery for Inflammatory Disease (Haim Burstein). Chapter 12: The Respiratory System as a Platform for Gene Delivery (Barrie J. Carter). Chapter 13: The Brain as a Target for Gene Therapy (Pedro R. Lowenstein and Maria G. Castro). Chapter 14: Immune Responses to Viral vectors Injected Systemically or into the CNS (Pedro R. Lowenstein and Maria G. Castro). Chapter 15: Cancer vaccines (Rimas J. Orentas). Chapter 16: Genetically Modified T cells for Human Gene Therapy (James L. Riley and Carl June). Chapter 17: Lentiviral Vector Delivery of RNAi Triggers for the Treatment of HIV-1 Infection (Kevin V. Morris ands John J. Rossi). Manufacture. Chapter 18: The Manufacture of Genetic Viral Vector Products (Douglas J. Jolly and Estuardo Aguilar-Cordova). Chapter 19: The Manufacture of Adeno-associated Viral Vectors (Richard Peluso). Chapter 20: Lentivirus Vector Manufacturing (Gwendolyn K.Binder and Boro Bropulic). Safety and Regulatory. Chapter 21: Assays for the Release of Viral Vector Gene Therapy Products for Clinical Trials (Flavia Borellini). Chapter 22: Safety of Retroviral Vectors: Regulatory and Technical Considerations (Kenneth Cornetta and Carolyn Wilson). Chapter 23: Assays for the Quality Control of Lentiviral Vectors (James Miskin, Susan M. Kingsman, and Kyriacos A. Mitrophanous). Chapter 24: Assays for Non-viral vectors (Ralph W. Paul). Chapter 25: Assays for the Release of Cellular Gene Therapy Products (Philip J. Cross and Bruce L. Levine). Chapter 26: Toxicology for Gene Therapy Products: Concepts and Challenges (Russette M. Lyons). Chapter 27: Regulatory Aspects of Gene Therapy Medicinal Products in the European Union (Matthias Schweizer, Christian Buchholz and Klaus Cichutek). Finance and Reimbursment. Chapter 28: Venture Capital and Biotechnology Startups (Douglas D. Lind). Chapter 29: The role of Investment Banking in the Growth of Biotechnology Companies (Douglas J. Swirsky). Chapter 30: Managing Reimbursment for Gene Therapy Products (Martin Gold).
Release date NZ
March 11th, 2008
Contributors
Edited by Barrie Carter Edited by Boro Dropulic
Country of Publication
United Kingdom
Illustrations
Illustrations
Imprint
Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
Pages
378
Dimensions
164x235x25
ISBN-13
9780471703204
Product ID
3082958

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