Rebecca Hall, a lovely young nurse from Louisiana, travels with her family to a thriving riverboat town on the Ohio River, before the turn of the century and eventually marries Charles Thain. Rebecca believes that she has found happiness with Charles, but things quickly deteriorate and their marriage ends in tragedy, putting into motion the nightmare that has haunted her since her early days in Louisiana, when a notorious voodoo witch, Grandma Phoebe, cursed her. Rebecca finds herself embroiled in circumstances beyond her knowledge of nursing when she becomes the victim of a series of attacks by a predator bent on killing her as he has other young women in the city. Her journey leads her through an intricacy of deceit before she can separate the truth from the facade.