This publication presents the structure and function of biological membranes to improve the understanding of cells in both normal and pathogenic states. Recently, vast amounts of new information have been accumulated, especially about pathological conditions, and there is now much evidence correlating genotypes and phenotypes in normal and disease states. This book surveys the most recent findings in research on the molecular biology, biochemistry, and genetics of the membranes of human red blood cells.
Table of Contents
Preface.Foreword.Acknowledgements.1. Introduction: History of Red Cell Membrane Research.2. Composition of Normal Red Cell Membranes.3. Stereotactic Structure of Red Cell Membranes.4. Skeletal Proteins.5. Integral Proteins.6. Anchoring Proteins.7. Membrane Morphogenesis in Erythroid Cells.8. States of Methylation in the Promoter of the Genes of beta-Spectrin, Band 3, and Protein 4.2.9. Disease States of Red Cell Membranes: Their Genotypes and Phenotypes.10. Hereditary Spherocytosis.11. Hereditary Elliptocytosis (HE).12. Hereditary Stomatocytosis.13. Acanthocytosis and Its Related Disorders.14. Abnormalities of Skeletal Proteins.15. Abnormalities of Integral Proteins and Blood Group Antigens.16. Abnormalities of Anchoring Proteins.17. Abnormalities of Membrane Lipids.18. Closing Remarks.Index.