Case Studies in Immunology, Fifth Edition cites major topics of immunology as the background to a selection of real clinical cases that serve to reinforce and extend the basic science. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. As well as being a valuable review aid, Case Studies in Immunology introduces in a clinical setting the major common disorders of immunity, including hypersensitivity types I-IV and autoimmune disorders such as lupus and multiple sclerosis. It also describes and explains the consequences of some of the most important immune deficiencies. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the disease or disorder. An end-of-case summary, questions, and discussion points finish each case. Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway's Immunobiology, Seventh Edition (ISBN 0-8153-4123-9) and The Immune System, Third Edition (ISBN 0-8153-4146-8).
Table of Contents
1.Congenital Asplenia 2. Chronic Granulomatous Disease 3. Leukocyte Adhesion Deficiency 4. Hereditary Angioneurotic Edema 5. Factor I Deficiency 6. Deficiency of the C8 Complement Component 7. Hereditary Periodic Fever Syndromes 8. Interleukin Receptor-associated Kinase Deficiency 9. X-linked Hypohydrotic Ectodermal Dysplasia and Immunodeficiency 10. X-linked Agammaglobulinemia 11. X-linked Hyper IgM Syndrome 12. Activation-induced Cytidine Deaminase (AID) Deficiency 13. Common Variable Immunodeficiency 14. X-linked Severe Combined Immunodeficiency 15. Adenosine Deaminase Deficiency 16. Omenn Syndrome 17. MHC Class I Deficiency 18. MHC Class II Deficiency 19. Multiple Myeloma 20. T-Cell Lymphoma 21. Interferon-y Receptor Deficiency 22. Wiskott-Aldrich Syndrome 23. X-linked Lymphoproliferative Syndrome 24. Autoimmune Lymphoproliferative Syndrome (ALPS) 25. Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked Disease 26. Toxic Shock Syndrome 27. Acute Infectious Mononucleosis 28. Mixed Essential Cryoglobulinemia 29. Rheumatic Fever 30. Lepromatous Leprosy 31. Acquired Immune Deficiency Syndrome (AIDS) 32. Acute Systemic Anaphylaxis 33. Allergic Asthma 34. Atopic Dermatitis 35. Drug-Induced Serum Sickness 36. Celiac Disease 37. Contact Sensitivity to Poison Ivy 38. Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) 39. Autoimmune Hemolytic Anemia 40. Myasthenia Gravis 41. Pemphigus Vulgaris 42. Rheumatoid Arthritis 43. Systemic Lupus Erythematosus 44. Multiple Sclerosis 45. Hemolytic Disease of the Newborn 46. A Kidney Graft for Complications of Autoimmune Insulin-Dependent Diabetes Mellitus 47.Graft-Versus-Host Disease
Raif S. Geha is the Prince Turki Al-Saud Professor of Pediatrics at the Harvard Medical School, Chief of the Division of Immunology at Boston's Children's Hospital, and is a practicing clinician doing research on immunity. Fred S. Rosen (deceased) had a long and distinguished career in which he has combined clinical practice in immunodeficiency diseases with cutting-edge research on basic mechanisms in immunity. Dr. Rosen was affiliated with Department of Pediatrics and the Center for Blood Research at the Harvard Medical School.