This book opens up a new approach for clinicians, already bombarded with an overwhelming amount of information and wanting to apply evidence-based medicine. Unlike usual sequential analysis of clinical trials, this book brings into sharp focus the essential points of more than 400 clinical studies. The central themes derived from this cross-sectional analysis constitute a modern over view of cardiovascular therapeutics.
Table of Contents
Hypertension Hypertension and cerebrovascular accidents How far should blood pressure be lowered? The J-curve The controversy concerning calcium channel blockers Hypercholesterolemia Primary prevention Trials conducted with diet alone Multifactorial trials Studies conducted with lipid-lowering drugs Secondary prevention Studies conducted with diet alone Studies conducted with lipid-lowering drugs Regression of atherosclerosis Anatomical results (femoral and carotid arteries) Anatomical results (coronary arteries) Clinical consequences Antithrombotic drugs in primary prevention of coronary heart disease Stable angina and silent myocardial ischemia Mechanism of action of antianginal drugs Unstable angina New antithrombotic drugs Acute myocardial infarction Open artery theory validated by the GUSTO I trial Characteristics of thrombolytic agents Comparative efficacy of thrombolytic agents Thrombolysis as a function of age Post-myocardial infarction Place of beta-blockers Place of angiotensin-converting enzyme inhibitors Chronic heart failure The controversy concerning digitalis glucosides Beta-blockers treatment in heart failure Atrial fibrillation Thromboembolic accident prevention trials Ventricular tachycardia and ventricular fibrillation Venous thromboembolism Heart valve prostheses and anticoagulants