An antimicrobial is a substance that kills or inhibits the growth of microbes such as bacteria, fungi, or viruses. Antimicrobial drugs either kill microbes (microbicidal) or prevent the growth of microbes (microbiostatic). The discovery of antimicrobials like penicillin and tetracycline paved the way for better health for millions around the world. Before 1941, the year penicillin was discovered; no true cure for gonorrhea, strep throat, or pneumonia existed. Patients with infected wounds often had to have a wounded limb removed, or face death from infection. This book focuses on insights of novel compounds and their antimicrobial activity by disc diffusion technique and can be utilized for research oriented studies and further developments in such drug discovery process.